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Psychedelics are a hallucinogenic class of psychoactive drug whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or “trips” ) via serotonin 2A receptor agonism. This causes specific psychological, visual and auditory changes, and often a substantially altered state of consciousness. “Classical” psychedelic drugs include mescaline, LSD, psilocybin, and DMT.

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Many psychedelic drugs are illegal worldwide under the UN conventions, occasionally excepting use in a religious or research context. Despite these controls, recreational use of psychedelics is common.

Classic psychedelics are considered to be those found in nature like psilocybin, DMT, mescaline, and LSD which is derived from naturally occurring ergotamine, and non-classic psychedelics are considered to be newer analogs and derivatives of pharmacophore lysergamides, tryptamine, and phenethylamine structures like 2C-B. Many of these psychedelics cause remarkably similar effects, despite their different chemical structure. However, many users report that the three major families have subjectively different qualities in the “feel” of the experience, which are difficult to describe. Some compounds, such as 2C-B, have extremely tight “dose curves”, meaning the difference in dose between a non-event and an overwhelming disconnection from reality can be very slight.

There can also be very substantial differences between the drugs; for instance, 5-MeO-DMT rarely produces the visual effects typical of other psychedelics. Tryptamines are well documented to cause classic psychedelic states, such as increased empathy, visual distorsions (drifting, morphing, breathing, melting of various surfaces and objects), auditory hallucinations, ego dissolution or ego death with high enough dose, mystical and spiritual experiences, closed eye hallucinations and complete detachment from reality with a high enough dose.

Potential Adverse Effects of Psychedelic drugs

Despite the contrary perception of much of the public, psychedelic drugs are not addictive and are physiologically safe. There is also no evidence that they cause long-term harm to mental health. As of 2016, there have been no known deaths due to overdose of LSD, psilocybin, or mescaline.

Psilocybin is safe when administered to a properly screened patient and supervised by a qualified professional with appropriate set and setting